Prof. Dr. Roland Robert Regös

Lecturer at the Department of Environmental Systems Science

ETH Zürich

Institut für Integrative Biologie

CHN H 76.2

Universitätstrasse 16

8092 Zürich

Switzerland

Additional information

Course Catalogue

Spring Semester 2025

Number	Unit
701-1708-00L	Infectious Disease Dynamics

Publications

2021 | 2020 | 2019 | 2018 | 2017 | Before 2017 |

2021

Igler C, Rolff J, Regös RR

Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens.

2021, Elife
PDF DOI

Rodríguez-Rojas A, Baeder D, Johnston P, Regös RR, Rolff J

Bacteria primed by antimicrobial peptides develop tolerance and persist.

2021, PLoS Pathog
PDF DOI

Hangartner L, Beauparlant D, Rakasz E, Nedellec R, Hozé N, Mckenney K, Martins M, Seabright G, Allen J, Weiler A, Friedrich T, Regös RR, Crispin M, Burton D

Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates.

2021, Sci Transl Med
PDF DOI

Bouman J, Riou J, Bonhoeffer S, Regös RR

Estimating the cumulative incidence of SARS-CoV-2 with imperfect serological tests: Exploiting cutoff-free approaches.

2021, PLoS Comput Biol
PDF DOI

2020

Caudill V, Qin S, Winstead R, Kaur J, Tisthammer K, Pineda E, Solis C, Cobey S, Bedford T, Carja O, Eggo R, Koelle K, Lythgoe K, Regös RR, Roy S, Allen N, Aviles M, Baker B, Bauer W, Bermudez S, Carlson C, Castellanos E, Catalan F, Chemel A, Elliot J, Evans D, Fiutek N, Fryer E, Goodfellow S, Hecht M, Hopp K, Hopson E, Jaberi A, Kinney C, Lao D, Le A, Lo J, Lopez A, López A, Lorenzo F, Luu G, Mahoney A, Melton R, Nascimento G, Pradhananga A, Rodrigues N, Shieh A, Sims J, Singh R, Sulaeman H, Thu R, Tran K, Tran L, Winters E, Wong A, Pennings P

CpG-creating mutations are costly in many human viruses.

2020, Evol Ecol
PDF DOI

Bons E, Leemann C, Metzner K, Regös RR

Long-term experimental evolution of HIV-1 reveals effects of environment and mutational history.

2020, PLoS Biol
PDF DOI

Ashcroft P, Huisman JS, Lehtinen S, Bouman J, Althaus C, Regös RR, Bonhoeffer S

COVID-19 infectivity profile correction.

2020, Swiss Med Wkly
DOI

Villabona-Arenas C, Hall M, Lythgoe K, Gaffney S, Regös RR, Hué S, Atkins K

Number of HIV-1 founder variants is determined by the recency of the source partner infection.

2020, Science
PDF DOI

Hausmann A, Böck D, Geiser P, Berthold D, Fattinger S, Furter M, Bouman J, Barthel-Scherrer M, Lang C, Bakkeren E, Kolinko I, Diard M, Bumann D, Slack E, Regös RR, Pilhofer M, Sellin M, Hardt W

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression.

2020, Mucosal Immunol
PDF DOI

Ben-Ami F, Orlic C, Regös RR

Disentangling non-specific and specific transgenerational immune priming components in host-parasite interactions.

2020, Proc Biol Sci
PDF DOI

2019

Bakkeren E, Huisman JS, Fattinger S, Hausmann A, Furter M, Egli A, Slack E, Sellin M, Bonhoeffer S, Regös RR, Diard M, Hardt W

Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut.

2019, Nature
PDF DOI

Bertels F, Leemann C, Metzner K, Regös RR

Parallel evolution of HIV-1 in a long-term experiment.

2019, Mol Biol Evol
PDF DOI

2018

Bons E, Regös RR

Virus dynamics and phyloanatomy: Merging population dynamic and phylogenetic approaches.

2018, Immunol Rev
DOI

Bons E, Bertels F, Regös RR

Estimating the mutational fitness effects distribution during early HIV infection.

2018, Virus Evol
PDF DOI

Hozé N, Bonhoeffer S, Regös RR

Assessing the public health impact of tolerance-based therapies with mathematical models.

2018, PLoS Comput Biol
PDF DOI

Yu G, Bäder DY, Regös RR, Rolff J

Predicting drug resistance evolution: insights from antimicrobial peptides and antibiotics.

2018, Proc Biol Sci
PDF DOI

Goldschmidt F, Regös RR, Johnson D

Metabolite toxicity slows local diversity loss during expansion of a microbial cross-feeding community.

2018, ISME J
PDF DOI

Bertels F, Marzel A, Leventhal G, Mitov V, Fellay J, Günthard H, Böni J, Yerly S, Klimkait T, Aubert V, Battegay M, Rauch A, Cavassini M, Calmy A, Bernasconi E, Schmid P, Scherrer A, Müller V, Bonhoeffer S, Kouyos R, Regös RR, Swiss Hiv Cohort Study C

Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity.

2018, Mol Biol Evol
PDF DOI

2017

Gabel M, Regös RR, Graw F

More or less-On the influence of labelling strategies to infer cell population dynamics.

2017, PLoS One
PDF DOI

Goldschmidt F, Regös RR, Johnson D

Successive range expansion promotes diversity and accelerates evolution in spatially structured microbial populations.

2017, ISME J
PDF DOI

Brandenberg O, Magnus C, Rusert P, Günthard H, Regös RR, Trkola A

Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters.

2017, PLoS Pathog
PDF DOI

Moor K, Diard M, Sellin M, Felmy B, Wotzka S, Toska A, Bakkeren E, Arnoldini M, Bansept F, Co A, Völler T, Minola A, Fernandez-Rodriguez B, Agatic G, Barbieri S, Piccoli L, Casiraghi C, Corti D, Lanzavecchia A, Regös RR, Loverdo C, Stocker R, Brumley D, Hardt W, Slack E

High-avidity IgA protects the intestine by enchaining growing bacteria.

2017, Nature
DOI

Before 2017

top

Kaiser P, Regös RR, Hardt W

Population Dynamics Analysis of Ciprofloxacin-Persistent S. Typhimurium Cells in a Mouse Model for Salmonella Diarrhea.

2016, Methods Mol Biol
DOI

Rusert P, Kouyos R, Kadelka C, Ebner H, Schanz M, Huber M, Braun D, Hozé N, Scherrer A, Magnus C, Weber J, Uhr T, Cippa V, Thorball C, Kuster H, Cavassini M, Bernasconi E, Hoffmann M, Calmy A, Battegay M, Rauch A, Yerly S, Aubert V, Klimkait T, Böni J, Fellay J, Regös RR, Günthard H, Trkola A, Swiss Hiv Cohort Study C

Determinants of HIV-1 broadly neutralizing antibody induction.

2016, Nat Med
DOI

Bäder DY, Yu G, Hozé N, Rolff J, Regös RR

Antimicrobial combinations: Bliss independence and Loewe additivity derived from mechanistic multi-hit models.

2016, Philos Trans R Soc Lond B Biol Sci
PDF DOI

Garcia V, Feldman M, Regös RR

Investigating the Consequences of Interference between Multiple CD8+ T Cell Escape Mutations in Early HIV Infection.

2016, PLoS Comput Biol
PDF DOI

Yu G, Bäder DY, Regös RR, Rolff J

Combination Effects of Antimicrobial Peptides.

2016, Antimicrob Agents Chemother
PDF DOI

Regös RR, Magnus C

The role of chance in primate lentiviral infectivity: from protomer to host organism.

2015, Prog Mol Biol Transl Sci
DOI

Brandenberg O, Magnus C, Regös RR, Trkola A

The HIV-1 Entry Process: A Stoichiometric View.

2015, Trends Microbiol
DOI

Maier L, Diard M, Sellin M, Chouffane E, Trautwein-Weidner K, Periaswamy B, Slack E, Dolowschiak T, Stecher B, Loverdo C, Regös RR, Hardt W

Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis.

2015, PLoS Pathog
PDF DOI

Garcia V, Richter K, Graw F, Oxenius A, Regös RR

Estimating the In Vivo Killing Efficacy of Cytotoxic T Lymphocytes across Different Peptide-MHC Complex Densities.

2015, PLoS Comput Biol
PDF DOI

Rahnamaeian M, Cytryńska M, Zdybicka-Barabas A, Dobslaff K, Wiesner J, Twyman R, Zuchner T, Sadd B, Regös RR, Schmid-Hempel P, Vilcinskas A

Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria.

2015, Proc Biol Sci
PDF DOI

Johnson S, Bergthaler A, Graw F, Flatz L, Bonilla W, Siegrist C, Lambert P, Regös RR, Pinschewer D

Protective efficacy of individual CD8+ T cell specificities in chronic viral infection.

2015, J Immunol
PDF DOI

Brandenberg O, Magnus C, Rusert P, Regös RR, Trkola A

Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry.

2015, PLoS Pathog
PDF DOI

Garcia V, Regös RR

The Effect of Interference on the CD8(+) T Cell Escape Rates in HIV.

2014, Front Immunol
PDF DOI

Maier L, Diard M, Sellin M, Chouffane E, Trautwein-Weidner K, Periaswamy B, Slack E, Dolowschiak T, Stecher B, Loverdo C, Regös RR, Hardt W

Granulocytes impose a tight bottleneck upon the gut luminal pathogen population during Salmonella typhimurium colitis.

2014, PLoS Pathog
PDF DOI

Graw F, Regös RR

Predicting the impact of CD8+ T cell polyfunctionality on HIV disease progression.

2014, J Virol
PDF DOI

Regös RR, Mclaren P, Battegay M, Bernasconi E, Calmy A, Günthard H, Hoffmann M, Rauch A, Telenti A, Fellay J, Swiss Hiv Cohort Study C

Disentangling human tolerance and resistance against HIV.

2014, PLoS Biol
PDF DOI

Brandenberg O, Rusert P, Magnus C, Weber J, Böni J, Günthard H, Regös RR, Trkola A

Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation.

2014, Retrovirology
PDF DOI

Kaiser P, Regös RR, Dolowschiak T, Wotzka S, Lengefeld J, Slack E, Grant A, Ackermann M, Hardt W

Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment.

2014, PLoS Biol
PDF DOI

Seich Al Basatena N, Chatzimichalis K, Graw F, Frost S, Regös RR, Asquith B

Can non-lytic CD8+ T cells drive HIV-1 escape?

2013, PLoS Pathog
PDF DOI

Magnus C, Brandenberg O, Rusert P, Trkola A, Regös RR

Mathematical models: a key to understanding HIV envelope interactions?

2013, J Immunol Methods
DOI

Kaiser P, Slack E, Grant A, Hardt W, Regös RR

Lymph node colonization dynamics after oral Salmonella Typhimurium infection in mice.

2013, PLoS Pathog
PDF DOI

Diard M, Garcia V, Maier L, Remus-Emsermann M, Regös RR, Ackermann M, Hardt W

Stabilization of cooperative virulence by the expression of an avirulent phenotype.

2013, Nature
DOI

Regös RR, Hamblin S, Tanaka M

Viral mutation rates: modelling the roles of within-host viral dynamics and the trade-off between replication fidelity and speed.

2013, Proc Biol Sci
PDF DOI

Graw F, Regös RR

Influence of the fibroblastic reticular network on cell-cell interactions in lymphoid organs.

2012, PLoS Comput Biol
PDF DOI

Magnus C, Regös RR

Analysis of the subunit stoichiometries in viral entry.

2012, PLoS One
PDF DOI

Regös RR

The role of exposure history on HIV acquisition: insights from repeated low-dose challenge studies.

2012, PLoS Comput Biol
PDF DOI

Graw F, Richter K, Oxenius A, Regös RR

Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection.

2011, Proc Biol Sci
PDF DOI

Magnus C, Regös RR

Restricted occupancy models for neutralization of HIV virions and populations.

2011, J Theor Biol
DOI

Rusert P, Krarup A, Magnus C, Brandenberg O, Weber J, Ehlert A, Regös RR, Günthard H, Trkola A

Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies.

2011, J Exp Med
PDF DOI

Johnson P, Kochin B, Mcafee M, Stromnes I, Regös RR, Ahmed R, Blattman J, Antia R

Vaccination alters the balance between protective immunity, exhaustion, escape, and death in chronic infections.

2011, J Virol
PDF DOI

Ruprecht C, Krarup A, Reynell L, Mann A, Brandenberg O, Berlinger L, Abela I, Regös RR, Günthard H, Rusert P, Trkola A

MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1.

2011, J Exp Med
PDF DOI

Zur Wiesch P, Kouyos R, Engelstädter J, Regös RR, Bonhoeffer S

Population biological principles of drug-resistance evolution in infectious diseases.

2011, Lancet Infect Dis
DOI

Takizawa H, Regös RR, Boddupalli C, Bonhoeffer S, Manz M

Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation.

2011, J Exp Med
PDF DOI

Graw F, Magnus C, Regös RR

Correction: Theoretical analysis of the evolution of immune memory

2011, BMC Evol Biol
PDF

Alizon S, Luciani F, Regös RR

Epidemiological and clinical consequences of within-host evolution.

2011, Trends Microbiol
DOI

Graw F, Magnus C, Regös RR

Theoretical analysis of the evolution of immune memory.

2010, BMC Evol Biol
PDF DOI

Regös RR

Population genetics meets cancer genomics.

2010, Proc Natl Acad Sci U S A
PDF DOI

Kouyos R, Gordon S, Staprans S, Silvestri G, Regös RR

Similar impact of CD8+ T cell responses on early virus dynamics during SIV infections of rhesus macaques and sooty mangabeys.

2010, PLoS Comput Biol
PDF DOI

Magnus C, Regös RR

Estimating the stoichiometry of HIV neutralization.

2010, PLoS Comput Biol
PDF DOI

Ben-Ami F, Ebert D, Regös RR

Pathogen dose infectivity curves as a method to analyze the distribution of host susceptibility: a quantitative assessment of maternal effects after food stress and pathogen exposure.

2010, Am Nat
DOI

Graw F, Regös RR

Investigating CTL mediated killing with a 3D cellular automaton.

2009, PLoS Comput Biol
PDF DOI

Magnus C, Rusert P, Bonhoeffer S, Trkola A, Regös RR

Estimating the stoichiometry of human immunodeficiency virus entry.

2009, J Virol
PDF DOI

Fouchet D, Regös RR

A population dynamics analysis of the interaction between adaptive regulatory T cells and antigen presenting cells.

2008, PLoS One
PDF DOI

Ben-Ami F, Regös RR, Ebert D

A quantitative test of the relationship between parasite dose and infection probability across different host-parasite combinations.

2008, Proc Biol Sci
PDF DOI

Salathé M, Kouyos R, Regös RR, Bonhoeffer S

Rapid parasite adaptation drives selection for high recombination rates.

2008, Evolution
DOI

Yates A, Graw F, Barber D, Ahmed R, Regös RR, Antia R

Revisiting estimates of CTL killing rates in vivo.

2007, PLoS One
PDF DOI

Mandl J, Regös RR, Garber D, Feinberg M

Estimating the effectiveness of simian immunodeficiency virus-specific CD8+ T cells from the dynamics of viral immune escape.

2007, J Virol
PDF DOI

Débarre F, Bonhoeffer S, Regös RR

The effect of population structure on the emergence of drug resistance during influenza pandemics.

2007, J R Soc Interface
PDF DOI

Regös RR, Yates A, Antia R

Mathematical models of cytotoxic T-lymphocyte killing.

2007, Immunol Cell Biol
DOI

Handel A, Regös RR, Antia R

Correction: The Role of Compensatory Mutations in the Emergence of Drug Resistance

2007, PLoS Comput Biol
PDF

Regös RR, Barber D, Ahmed R, Antia R

Estimation of the rate of killing by cytotoxic T lymphocytes in vivo.

2007, Proc Natl Acad Sci U S A
PDF DOI

Yates A, Antia R, Regös RR

How do pathogen evolution and host heterogeneity interact in disease emergence?

2006, Proc Biol Sci
PDF DOI

Bull J, Regös RR

Pharmacodynamics of non-replicating viruses, bacteriocins and lysins.

2006, Proc Biol Sci
PDF DOI

Handel A, Regös RR, Antia R

The role of compensatory mutations in the emergence of drug resistance.

2006, PLoS Comput Biol
PDF DOI

Regös RR, Bowen E, Cope A, Gor D, Hassan-Walker A, Prentice H, Johnson M, Sweny P, Burroughs A, Griffiths P, Bonhoeffer S, Emery V

Modelling cytomegalovirus replication patterns in the human host: factors important for pathogenesis.

2006, Proc Biol Sci
PDF DOI

Regös RR, Bonhoeffer S

Emergence of drug-resistant influenza virus: population dynamical considerations.

2006, Science
DOI

Regös RR, Longini I, Feinberg M, Staprans S

Preclinical assessment of HIV vaccines and microbicides by repeated low-dose virus challenges.

2005, PLoS Med
PDF DOI

Regös RR, Bonhoeffer S

The HIV coreceptor switch: a population dynamical perspective.

2005, Trends Microbiol
DOI

Wiuff C, Zappala R, Regös RR, Garner K, Baquero F, Levin B

Phenotypic tolerance: antibiotic enrichment of noninherited resistance in bacterial populations.

2005, Antimicrob Agents Chemother
PDF DOI

Regös RR, Crotty S, Antia R, Tanaka M

Optimal replication of poliovirus within cells.

2005, Am Nat
DOI

Regös RR, Wiuff C, Zappala R, Garner K, Baquero F, Levin B

Pharmacodynamic functions: a multiparameter approach to the design of antibiotic treatment regimens.

2004, Antimicrob Agents Chemother
PDF DOI

Regös RR, Antia R, Garber D, Silvestri G, Feinberg M, Staprans S

Roles of target cells and virus-specific cellular immunity in primary simian immunodeficiency virus infection.

2004, J Virol
PDF DOI

Antia R, Regös RR, Koella J, Bergstrom C

The role of evolution in the emergence of infectious diseases.

2003, Nature
PDF DOI

Regös RR, Hottinger J, Sygnarski L, Ebert D

The infection rate of Daphnia magna by Pasteuria ramosa conforms with the mass-action principle.

2003, Epidemiol Infect
DOI

Regös RR, Bonhoeffer S

HIV coreceptor usage and drug treatment.

2002, J Theor Biol
DOI

Regös RR, Staprans S, Feinberg M, Bonhoeffer S

Contribution of peaks of virus load to simian immunodeficiency virus pathogenesis.

2002, J Virol
PDF DOI

Regös RR, Ebert D, Bonhoeffer S

Dose-dependent infection rates of parasites produce the Allee effect in epidemiology.

2002, Proc Biol Sci
PDF DOI

Regös RR, Nowak M, Bonhoeffer S

Evolution of virulence in a heterogeneous host population.

2000, Evolution
DOI

Regös RR, Wodarz , Nowak

Virus dynamics: the effect of target cell limitation and immune responses on virus evolution.

1998, J Theor Biol
DOI